The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
نویسندگان
چکیده
We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8+ T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy.
منابع مشابه
Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.
Stimulating the effector functions of tumor-infiltrating T lymphocytes (TIL) in primary and metastatic tumors could improve active and adoptive T-cell therapies for cancer. Abnormal glycolysis, high lactic acid production, proton accumulation, and a reversed intra-extracellular pH gradient are thought to help render tumor microenvironments hostile to roving immune cells. However, there is littl...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013